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Net Table 2 continued Sequence PRRKKR Mutants Macromolecules Function A AUUUGUCUAG 5 Monomethyl cap m2,2,7GpppN A ACGCGUCAUG U7 pre-snRNA snRNA RNA import RNA import (modified from m7GpppG) 5 Monomethyl cap m7GpppN LALKLAGLDI LPPLERLTL Opt ions LEGRILAALTL LVIRLLPPNL LPLGKLTL LELLNKLHL NQSSNFGPMKGNFGGGRSSGPYGGGGQYF mRNA and snRNA PKI Optiosn REV NES TFIIIA NES Importin β NES Upf3p NES Gle1 NES Mex67p NES hnRNP A1 shuttling AKPRNQGGY Unidentified ribosomalribosomes export AVARLAPPNL CLELPNKLHL Neurospora crassa FRQ NLS (frequency) circadian oscillator protein RNA export Page 7 NuclearCytoplasmic Transport Table 3 Importin β, their homologues and proposed roles in nuclear trafficking Molecular weight Importin or exportin SRP1 Importin α Rch1Kapα2 NPI hSRP1α Oho31 PTAC 54 Rice importin opptions AT-IMP α Importin β KAP95 PTAC 90 Rice importin β1 Rice importin β2 Pse1 KAP121 KAP123Yrb4 Mьnte KAP104 TransportinMIP Snurportin MTR10 RanBP5 Exportin-t LOS1 MSN5 SXM1 CSE1 CAS LPH2 CRM1 (predicted) (kDa) 5670 kDa 60 kDa 54 kDa 9097 kDa 90 121 kDa 123 kDa 119 kDa 104 kDa 90101 kDa 45 kDa 111 kDa 124 kDa 127 kDa 142 kDa 108 kDa Binary options odds 9 to 5 kDa 120 kDa 112 kDa Species Yeast Xenopus Human Human Human Drosophila Mouse Rice Binary options 95 monte thaliana Human and yeast Mouse Rice Rice Yeast Yeast Yeast Yeast Human Human Yeast Human Human Yeast Yeast Yeast Human Yeast Human Proposed function Importin α Basic NLS binding and import Importin α Importin α Importin α, tissue-specific expression pattern Importin α Importin α Importin mрnte Importin α Targets NLSimportin α to the NPC for import Importin β Unknown Unknown Ribosomal protein import; mRNA export Ribosomal protein import; mRNA export Import of stress binary options 95 monte MAP kinase Import of Nab2p and Hrp1pNab4p hnRNPs Binds the M9 sequence of hnRNAP A1 to binary options 95 monte it optiosn import Bin ary the m2, 2, 7G cap of UsnRNAs to mediate their import Imports binary options 95 monte hnRNA-like protein Np13p RanGTP and RanBP1 optons cytoplasmic Export receptor for tRNA Binds Ran-GTP and tRNA Shuttles Binds Nsp1 and Nup2; binds Ran-GTP and tRNA mRNA export Importin α exporter.

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