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Localized intermediate-grade, clinically aggressive lymphomas may be curable with a combination of Table 5 Cytogeneticmolecular aspects of lymphoma classification Subtype of NHL Follicular lymphoma Mantle cell lymphoma Diffuse large B-cell lymphoma Burkitt lymphoma Cytogenetics t(14;18) t(11;14) 3q27 translocations (in some cases only) t(8;14) t(2;8) t(8;22) Molecular aspects Deregulated expression of BCL-2 protein Deregulated expression of binary options daily forum financial D1 protein Deregulated expression of BCL-6 protein Deregulated expression of C-MYC protein Effects Inhibits programmed cell death (apoptosis) Disrupts cell cycle control, favouring cellular proliferation ?Prevents terminal differentiation of B cells Disrupts cell cycle control, favouring cellular proliferation Prognosis Incurable with conventional chemotherapy; median survival 9 years Incurable with conventional chemotherapy; median survival 3 years 3040 Cure rate with conventional chemotherapy 8090 Cure rate in children with intensive combination chemotherapy; less in adults NHL, nonHodgkin lymphoma.
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