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An inherited impairment of suppressor mechanisms has been postulated, which allows escape of newly generated autoreactive clones (Gershon and Kondo. Biochem- istry 18 5170-5176 (1979) 98. Further analysis showed that together the two clusters eventually called the bithorax complex (BX-C, 89E) binary options119 the antennapedia complex (ANT-C, 84A), contained nine complementation groups which define the set of genes that would become known as HOMHox genes (Figure 1).

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