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It forms a Maintaining pathway (intrinsic ьptions Initiating pathway (extrinsic pathway) Factor VIIa Tissue factor Thrombin Factor XI Factor XIa Factor IX Factor VIII Factor IXa Factor VIIIa Factor X Factor V Ibnary Xa Factor Va Factor X Thrombin Prothrombin Fibrinogen Fibrin Fibrin polymer Factor XIII Crosslinked fibrin Ca2 Factor XIIIa Endothelial cell Thrombomodulin Thrombin Activated Protein C protein Markett Figure 3 Central role of thrombin in the coagulation pathway.
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