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Amster- dam Elsevier. On the other hand, except for N. Efficacy can be measured by monitoring CD3 1 cells in the circulation. The decision to die is largely played out on the mitochondrial surface between three major families the so-called three horsemen of apoptosis. Loewe. The conjugation of poly-Ubq chains to target proteins requires the sequential action of Ubq-activating enzymes (E1), the Ubq-conjugating enzymes (E2), and E3 Ubq-ligase enzymes.
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