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Trends in Genetics 14 6672. 1997. Many aspects of bioassay design are controversial, especially the use of the B6C3F1 mouse and the use of the maximum tolerated dose. An example of such a protein is the family of G protein-coupled receptors that transduce signals from one side of the membrane to the other. In general terms, we describe how the engine is accelerated in response to go signals (appropriate cell size, proper nutrition) and how it is braked in response to stop signals (threats to genome integrity).
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