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net 5 Table 2 Collectins soluble lectins involved in pathogen recognition Collectin Mannose-binding lectin (MBL) Major carbohydrate ligands GlcAc Fuc, Man, ManNAc Major site of synthesis Hepatocytes Site of expression Plasma Primary function Opsonization, complement activation Surfactant protein A (SP-A) Surfactant protein D (SP-D) P35 ManNAcFuc Man, Glu Gal GlcNAc Alveolar type II cells Alveolar type II cells Liver Lung Lung Plasma (lectin pathway), phagocyte activation Opsonization, neutralization Opsonization (?), neutralization Opsonization GlcNAc, N-acetylglucosamine; Fuc, fucose; Man, mannose; ManNAc, N-acetylmannosamine; Glu, glucose; Gal, galactose.

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